Subject Firebird on the big iron 512G of ram 100.000 concurrent users
Author mariuz
And of course some issues with the lock table offsets
http://thread.gmane.org/gmane.comp.db.firebird.devel/934

The trend is to put everything in ram
http://37signals.com/svn/posts/3090-basecamp-nexts-caching-hardware
and to use SSD/FusionIO